go_id,ontology,go_term,term_definition,evidence
GO:0005057,MF,"receptor signaling protein activity","Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.",IEA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005543,MF,"phospholipid binding","Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.",IDA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0006672,BP,"ceramide metabolic process","The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.",NAS
GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA
GO:0012505,CC,"endomembrane system","A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.",IEA
GO:0016230,MF,"sphingomyelin phosphodiesterase activator activity","Increases the activity of the enzyme sphingomyelin phosphodiesterase.",IMP
GO:0019898,CC,"extrinsic component of membrane","The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.",IEA
GO:0043065,BP,"positive regulation of apoptotic process","Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.",ISS
GO:0043085,BP,"positive regulation of catalytic activity","Any process that activates or increases the activity of an enzyme.",IEA
GO:2000304,BP,"positive regulation of ceramide biosynthetic process","Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.",IEA