go_id,ontology,go_term,term_definition,evidence
GO:0004908,MF,"interleukin-1 receptor activity","Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.",IDA
GO:0004910,MF,"interleukin-1, Type II, blocking receptor activity","Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.",IEA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0006955,BP,"immune response","Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.",TAS
GO:0010955,BP,"negative regulation of protein processing","Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.",IC
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0019221,BP,"cytokine-mediated signaling pathway","A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.",IBA
GO:0019966,MF,"interleukin-1 binding","Interacting selectively and non-covalently with interleukin-1.",IDA
GO:0050712,BP,"negative regulation of interleukin-1 alpha secretion","Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell.",IEA
GO:1900016,BP,"negative regulation of cytokine production involved in inflammatory response","Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.",IDA
GO:2000660,BP,"negative regulation of interleukin-1-mediated signaling pathway","Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.",ISS