go_id,ontology,go_term,term_definition,evidence
GO:0001725,CC,"stress fiber","A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.",IDA
GO:0003674,MF,molecular_function,"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.",ND
GO:0003779,MF,"actin binding","Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.",IEA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0005856,CC,cytoskeleton,"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.",IBA
GO:0005862,CC,"muscle thin filament tropomyosin","A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.",TAS
GO:0006928,BP,"movement of cell or subcellular component","The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.",TAS
GO:0006936,BP,"muscle contraction","A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.",TAS
GO:0030049,BP,"muscle filament sliding","The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.",TAS
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA