go_id,ontology,go_term,term_definition,evidence
GO:0004866,MF,"endopeptidase inhibitor activity","Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.",TAS
GO:0004867,MF,"serine-type endopeptidase inhibitor activity","Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.",IDA
GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA
GO:0005615,CC,"extracellular space","That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",TAS
GO:0005783,CC,"endoplasmic reticulum","The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0007596,BP,"blood coagulation","The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.",TAS
GO:0007598,BP,"blood coagulation, extrinsic pathway","A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.",TAS
GO:0009986,CC,"cell surface","The external part of the cell wall and/or plasma membrane.",IDA
GO:0010951,BP,"negative regulation of endopeptidase activity","Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.",IEA
GO:0031090,CC,"organelle membrane","A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.",IEA
GO:0031225,CC,"anchored component of membrane","The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.",IEA
GO:0032355,BP,"response to estradiol","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.",IDA
GO:0071222,BP,"cellular response to lipopolysaccharide","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.",ISS
GO:0071347,BP,"cellular response to interleukin-1","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.",IEA