go_id,ontology,go_term,term_definition,evidence
GO:0000166,MF,"nucleotide binding","Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.",IEA
GO:0000375,BP,"RNA splicing, via transesterification reactions","Splicing of RNA via a series of two transesterification reactions.",TAS
GO:0000381,BP,"regulation of alternative mRNA splicing, via spliceosome","Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.",IDA|IMP
GO:0000398,BP,"mRNA splicing, via spliceosome","The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.",IGI
GO:0003729,MF,"mRNA binding","Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.",IBA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0005637,CC,"nuclear inner membrane","The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.",ISS
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0021796,BP,"cerebral cortex regionalization","The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.",IEA
GO:0036002,MF,"pre-mRNA binding","Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.",IDA
GO:0044822,MF,"poly(A) RNA binding","Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.",IDA
GO:0048025,BP,"negative regulation of mRNA splicing, via spliceosome","Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.",IDA
GO:0048026,BP,"positive regulation of mRNA splicing, via spliceosome","Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.",ISS
GO:0070717,MF,"poly-purine tract binding","Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule.",IEA
GO:1990403,BP,"embryonic brain development","The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.",IEA