go_id,ontology,go_term,term_definition,evidence
GO:0002521,BP,"leukocyte differentiation","The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.",IMP
GO:0003924,MF,"GTPase activity","Catalysis of the reaction: GTP + H2O = GDP + phosphate.",IEA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005525,MF,"GTP binding","Interacting selectively and non-covalently with GTP, guanosine triphosphate.",IEA
GO:0005622,CC,intracellular,"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.",IEA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005925,CC,"focal adhesion","Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.",IDA
GO:0007265,BP,"Ras protein signal transduction","A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.",IEA
GO:0019003,MF,"GDP binding","Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.",IDA
GO:0030336,BP,"negative regulation of cell migration","Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.",TAS
GO:0032403,MF,"protein complex binding","Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IEA
GO:0045766,BP,"positive regulation of angiogenesis","Any process that activates or increases angiogenesis.",IEA
GO:0051896,BP,"regulation of protein kinase B signaling","Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.",IMP
GO:0060325,BP,"face morphogenesis","The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.",ISS
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA
GO:0070372,BP,"regulation of ERK1 and ERK2 cascade","Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.",IDA