go_id,ontology,go_term,term_definition,evidence
GO:0000165,BP,"MAPK cascade","An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.",TAS
GO:0005096,MF,"GTPase activator activity","Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.",IEA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA
GO:0031235,CC,"intrinsic component of the cytoplasmic side of the plasma membrane","The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.",IBA
GO:0043547,BP,"positive regulation of GTPase activity","Any process that activates or increases the activity of a GTPase.",IEA
GO:0046580,BP,"negative regulation of Ras protein signal transduction","Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.",IBA
GO:0046872,MF,"metal ion binding","Interacting selectively and non-covalently with any metal ion.",IEA
GO:0048471,CC,"perinuclear region of cytoplasm","Cytoplasm situated near, or occurring around, the nucleus.",IDA