go_id,ontology,go_term,term_definition,evidence
GO:0001666,BP,"response to hypoxia","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.",IEA
GO:0005506,MF,"iron ion binding","Interacting selectively and non-covalently with iron (Fe) ions.",IEA
GO:0005789,CC,"endoplasmic reticulum membrane","The lipid bilayer surrounding the endoplasmic reticulum.",IEA
GO:0006464,BP,"cellular protein modification process","The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).",TAS
GO:0008475,MF,"procollagen-lysine 5-dioxygenase activity","Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.",TAS
GO:0008544,BP,"epidermis development","The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.",IEA
GO:0030867,CC,"rough endoplasmic reticulum membrane","The lipid bilayer surrounding the rough endoplasmic reticulum.",IEA
GO:0031418,MF,"L-ascorbic acid binding","Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.",IEA
GO:0042803,MF,"protein homodimerization activity","Interacting selectively and non-covalently with an identical protein to form a homodimer.",IEA
GO:0046947,BP,"hydroxylysine biosynthetic process","The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.",TAS
GO:0055114,BP,"oxidation-reduction process","A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.",IEA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA