go_id,ontology,go_term,term_definition,evidence
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0005739,CC,mitochondrion,"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.",IEA
GO:0005743,CC,"mitochondrial inner membrane","The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.",IEA
GO:0005747,CC,"mitochondrial respiratory chain complex I","A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.",IDA|IMP|NAS
GO:0006120,BP,"mitochondrial electron transport, NADH to ubiquinone","The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.",NAS|TAS
GO:0006979,BP,"response to oxidative stress","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.",TAS
GO:0008137,MF,"NADH dehydrogenase (ubiquinone) activity","Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.",IMP|NAS
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0031965,CC,"nuclear membrane","Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.",IEA
GO:0032981,BP,"mitochondrial respiratory chain complex I assembly","The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.",IMP|TAS
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA