go_id,ontology,go_term,term_definition,evidence
GO:0001958,BP,"endochondral ossification","Replacement ossification wherein bone tissue replaces cartilage.",IEA
GO:0004222,MF,"metalloendopeptidase activity","Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.",IMP|NAS|TAS
GO:0005509,MF,"calcium ion binding","Interacting selectively and non-covalently with calcium ions (Ca2+).",IDA
GO:0005578,CC,"proteinaceous extracellular matrix","A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.",IEA
GO:0005796,CC,"Golgi lumen","The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005887,CC,"integral component of plasma membrane","The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IDA
GO:0006508,BP,proteolysis,"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.",IEA
GO:0008047,MF,"enzyme activator activity","Binds to and increases the activity of an enzyme.",IDA
GO:0008270,MF,"zinc ion binding","Interacting selectively and non-covalently with zinc (Zn) ions.",IEA
GO:0009986,CC,"cell surface","The external part of the cell wall and/or plasma membrane.",IDA
GO:0016485,BP,"protein processing","Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.",IEA
GO:0019538,BP,"protein metabolic process","The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.",IDA
GO:0022617,BP,"extracellular matrix disassembly","A process that results in the breakdown of the extracellular matrix.",IMP
GO:0030574,BP,"collagen catabolic process","The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.",TAS
GO:0035988,BP,"chondrocyte proliferation","The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.",IEA
GO:0043085,BP,"positive regulation of catalytic activity","Any process that activates or increases the activity of an enzyme.",IEA
GO:0048701,BP,"embryonic cranial skeleton morphogenesis","The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.",ISS
GO:0070006,MF,"metalloaminopeptidase activity","Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.",IDA|TAS
GO:0097094,BP,"craniofacial suture morphogenesis","The process in which any suture between cranial and/or facial bones is generated and organized.",IEA