go_id,ontology,go_term,term_definition,evidence
GO:0004222,MF,"metalloendopeptidase activity","Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.",IMP|NAS|TAS
GO:0004252,MF,"serine-type endopeptidase activity","Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).",IDA|TAS
GO:0005509,MF,"calcium ion binding","Interacting selectively and non-covalently with calcium ions (Ca2+).",IDA
GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA
GO:0005578,CC,"proteinaceous extracellular matrix","A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.",IEA
GO:0005796,CC,"Golgi lumen","The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.",IDA
GO:0006508,BP,proteolysis,"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.",IEA
GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA
GO:0008270,MF,"zinc ion binding","Interacting selectively and non-covalently with zinc (Zn) ions.",IEA
GO:0022617,BP,"extracellular matrix disassembly","A process that results in the breakdown of the extracellular matrix.",IMP
GO:0030199,BP,"collagen fibril organization","Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.",IMP
GO:0030574,BP,"collagen catabolic process","The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.",TAS
GO:0045599,BP,"negative regulation of fat cell differentiation","Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.",ISS
GO:0071711,BP,"basement membrane organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.",ISS