go_id,ontology,go_term,term_definition,evidence GO:0001726,CC,ruffle,"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.",IDA GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA GO:0005938,CC,"cell cortex","The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.",IBA GO:0007160,BP,"cell-matrix adhesion","The binding of a cell to the extracellular matrix via adhesion molecules.",IDA GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA GO:0008360,BP,"regulation of cell shape","Any process that modulates the surface configuration of a cell.",IBA GO:0031532,BP,"actin cytoskeleton reorganization","A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.",ISS