go_id,ontology,go_term,term_definition,evidence
GO:0000122,BP,"negative regulation of transcription from RNA polymerase II promoter","Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IDA|ISS
GO:0000790,CC,"nuclear chromatin","The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.",IBA
GO:0000978,MF,"RNA polymerase II core promoter proximal region sequence-specific DNA binding","Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.",IDA
GO:0001078,MF,"transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding","Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IDA
GO:0003700,MF,"transcription factor activity, sequence-specific DNA binding","Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.",IMP
GO:0003712,MF,"transcription cofactor activity","Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.",TAS
GO:0003714,MF,"transcription corepressor activity","Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.",ISS
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA
GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA
GO:0008283,BP,"cell proliferation","The multiplication or reproduction of cells, resulting in the expansion of a cell population.",IEA
GO:0046983,MF,"protein dimerization activity","The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.",IEA