go_id,ontology,go_term,term_definition,evidence
GO:0005125,MF,"cytokine activity","Functions to control the survival, growth, differentiation and effector function of tissues and cells.",TAS
GO:0005150,MF,"interleukin-1, Type I receptor binding","Interacting selectively and non-covalently with a Type I interleukin-1 receptor.",IPI
GO:0005151,MF,"interleukin-1, Type II receptor binding","Interacting selectively and non-covalently with a Type II interleukin-1 receptor.",IPI
GO:0005152,MF,"interleukin-1 receptor antagonist activity","Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.",IDA|TAS
GO:0005615,CC,"extracellular space","That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",TAS
GO:0005622,CC,intracellular,"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.",IEA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0006629,BP,"lipid metabolic process","The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.",NAS
GO:0006955,BP,"immune response","Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.",TAS
GO:0030073,BP,"insulin secretion","The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.",IEA
GO:0034115,BP,"negative regulation of heterotypic cell-cell adhesion","Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.",IDA
GO:0045352,MF,"interleukin-1 Type I receptor antagonist activity","Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.",IDA
GO:0045353,MF,"interleukin-1 Type II receptor antagonist activity","Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.",IDA
GO:0051384,BP,"response to glucocorticoid","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.",IEA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA
GO:2000660,BP,"negative regulation of interleukin-1-mediated signaling pathway","Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.",ISS