go_id,ontology,go_term,term_definition,evidence
GO:0000400,MF,"four-way junction DNA binding","Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.",ISS
GO:0003690,MF,"double-stranded DNA binding","Interacting selectively and non-covalently with double-stranded DNA.",IDA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0005694,CC,chromosome,"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.",IEA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0006310,BP,"DNA recombination","Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.",IEA
GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA
GO:0006355,BP,"regulation of transcription, DNA-templated","Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.",IBA
GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA
GO:0008301,MF,"DNA binding, bending","The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.",ISS
GO:0032392,BP,"DNA geometric change","The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.",ISS
GO:0044822,MF,"poly(A) RNA binding","Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.",IDA
GO:0045087,BP,"innate immune response","Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.",IBA
GO:0045596,BP,"negative regulation of cell differentiation","Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.",IEA