Gene Ontology Description

GO ID GO:0070374
Ontology BP
GO Term positive regulation of ERK1 and ERK2 cascade
Definition Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

TLR4

toll-like receptor 4

7099

O00206

chr9: 117,704,332-117,716,871

NRP1

neuropilin 1

8829

O14786

chr10: 33,177,492-33,336,262

RIPK2

receptor interacting serine/threonine kinase 2

8767

O43353

chr8: 89,757,747-89,791,063

SPRY2

sprouty RTK signaling antagonist 2

10253

O43597

chr13: 80,335,976-80,340,951

SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

8482

O75326

chr15: 74,409,289-74,434,467

FGF18

fibroblast growth factor 18

8817

O76093

chr5: 171,419,656-171,457,623

FGF19

fibroblast growth factor 19

9965

O95750

chr11: 69,698,232-69,704,642

EGFR

epidermal growth factor receptor

1956

P00533

chr7: 55,019,021-55,211,628

PDGFB

platelet-derived growth factor beta polypeptide

5155

P01127

chr22: 39,223,359-39,244,751

GCG

glucagon

2641

P01275

chr2: 162,142,873-162,152,404

TNF

tumor necrosis factor

7124

P01375

chr6: 31,575,567-31,578,336

FGA

fibrinogen alpha chain

2243

P02671

chr4: 154,583,126-154,590,766

FGB

fibrinogen beta chain

2244

P02675

chr4: 154,562,956-154,571,086

FGG

fibrinogen gamma chain

2266

P02679

chr4: 154,604,134-154,612,967

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

3156

P04035

chr5: 75,336,329-75,362,104

PDGFA

platelet-derived growth factor alpha polypeptide

5154

P04085

chr7: 497,258-520,296

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

972

P04233

chr5: 150,401,637-150,412,929

NTRK1

neurotrophic tyrosine kinase, receptor, type 1

4914

P04629

chr1: 156,815,640-156,881,850

IL6

interleukin 6

3569

P05231

chr7: 22,725,884-22,732,002

ICAM1

intercellular adhesion molecule 1

3383

P05362

chr19: 10,270,835-10,286,615

JUN

jun proto-oncogene

3725

P05412

chr1: 58,780,788-58,784,327

CSF1R

colony stimulating factor 1 receptor

1436

P07333

chr5: 150,053,291-150,113,372

FGF2

fibroblast growth factor 2 (basic)

2247

P09038

chr4: 122,826,708-122,898,236

HMGB1

high mobility group box 1

3146

P09429

chr13: 30,456,704-30,617,597

PDGFRB

platelet-derived growth factor receptor, beta polypeptide

5159

P09619

chr5: 150,113,837-150,155,872

CCL3

chemokine (C-C motif) ligand 3

6348

P10147

chr17: 36,088,256-36,090,169

BMP2

bone morphogenetic protein 2

650

P12643

chr20: 6,767,664-6,780,280

BMP4

bone morphogenetic protein 4

652

P12644

chr14: 53,949,736-53,958,761

CCL4

chemokine (C-C motif) ligand 4

6351

P13236

chr17: 36,103,590-36,105,621

CCL2

chemokine (C-C motif) ligand 2

6347

P13500

chr17: 34,255,218-34,257,203

CCL5

chemokine (C-C motif) ligand 5

6352

P13501

chr17: 35,871,491-35,880,793

MIF

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

4282

P14174

chr22: 23,894,004-23,895,227

DRD2

dopamine receptor D2

1813

P14416

chr11: 113,409,615-113,475,691

PLA2G2A

phospholipase A2 group IIA

5320

P14555

chr1: 19,975,431-19,980,416

ALOX15

arachidonate 15-lipoxygenase

246

P16050

chr17: 4,630,902-4,642,294

CD44

CD44 molecule (Indian blood group)

960

P16070

chr11: 35,138,870-35,232,402

NQO2

NAD(P)H dehydrogenase, quinone 2

4835

P16083

chr6: 2,987,987-3,028,869

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

5156

P16234

chr4: 54,229,097-54,298,247

CD36

CD36 molecule (thrombospondin receptor)

948

P16671

chr7: 80,369,575-80,679,277

PRKCA

protein kinase C, alpha

5578

P17252

chr17: 66,302,636-66,810,743

C5AR1

complement component 5a receptor 1

728

P21730

chr19: 47,290,023-47,322,066

FGFR2

fibroblast growth factor receptor 2

2263

P21802

chr10: 121,478,334-121,598,458

FSHR

follicle stimulating hormone receptor

2492

P23945

chr2: 48,962,157-49,154,537

F2R

coagulation factor II (thrombin) receptor

2149

P25116

chr5: 76,716,043-76,735,781

MT3

metallothionein 3

4504

P25713

chr16: 56,589,074-56,591,088

MAPK3

mitogen-activated protein kinase 3

5595

P27361

chr16: 30,114,105-30,123,506

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

3358

P28335

chrX: 114,584,078-114,910,061

CTGF

connective tissue growth factor

1490

P29279

chr6: 131,948,176-131,951,373

S100A7

S100 calcium binding protein A7

6278

P31151

chr1: 153,457,744-153,460,701

GPR183

G protein-coupled receptor 183

1880

P32249

chr13: 99,294,530-99,307,405

PHB

prohibitin

5245

P35232

chr17: 49,404,049-49,414,905

ADRA1A

adrenoceptor alpha 1A

148

P35348

chr8: 26,748,150-26,867,273

FLT4

fms-related tyrosine kinase 4

2324

P35916

chr5: 180,601,506-180,649,624

CHI3L1

chitinase 3 like 1

1116

P36222

chr1: 203,178,931-203,186,749

MAP2K2

mitogen-activated protein kinase kinase 2

5605

P36507

chr19: 4,090,321-4,124,129

PLA2G5

phospholipase A2 group V

5322

P39877

chr1: 20,028,179-20,091,190

HTR2B

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

3357

P41595

chr2: 231,108,230-231,125,118

F2RL1

coagulation factor II (thrombin) receptor-like 1

2150

P55085

chr5: 76,818,933-76,835,315

TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

114609

P58753

chr11: 126,283,065-126,298,845

PTEN

phosphatase and tensin homolog

5728

P60484

chr10: 87,863,113-87,971,930

RAP1A

RAP1A, member of RAS oncogene family

5906

P62834

chr1: 111,542,218-111,716,691

CCL20

chemokine (C-C motif) ligand 20

6364

P78556

chr2: 227,813,842-227,817,564

CCL8

chemokine (C-C motif) ligand 8

6355

P80075

chr17: 34,319,036-34,321,402

MAP2K1

mitogen-activated protein kinase kinase 1

5604

Q02750

chr15: 66,386,817-66,492,312

TEK

TEK tyrosine kinase, endothelial

7010

Q02763

chr9: 27,109,141-27,230,175

PTPN11

protein tyrosine phosphatase, non-receptor type 11

5781

Q06124

chr12: 112,418,351-112,509,913

CAMK2D

calcium/calmodulin-dependent protein kinase II delta

817

Q13557

chr4: 113,451,032-113,761,927

GAS6

growth arrest specific 6

2621

Q14393

chr13: 113,820,549-113,864,067

ERBB4

erb-b2 receptor tyrosine kinase 4

2066

Q15303

chr2: 211,375,717-212,538,841

ANGPT1

angiopoietin 1

284

Q15389

chr8: 107,249,482-107,498,055

NPY5R

neuropeptide Y receptor Y5

4889

Q15761

chr4: 163,343,939-163,351,934

FAM150B

family with sequence similarity 150 member B

285016

Q6UX46

chr2: 279,558-288,851

DSTYK

dual serine/threonine and tyrosine protein kinase

25778

Q6XUX3

chr1: 205,142,505-205,211,566

GCNT2

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)

2651

Q8N0V5

chr6: 10,492,223-10,629,368

BMPER

BMP binding endothelial regulator

168667

Q8N8U9

chr7: 33,904,911-34,155,872

PRKCDBP

protein kinase C, delta binding protein

112464

Q969G5

chr11: 6,318,946-6,320,647

GPER1

G protein-coupled estrogen receptor 1

2852

Q99527

chr7: 1,082,208-1,093,815

PHB2

prohibitin 2

11331

Q99623

chr12: 6,965,327-6,970,825

CIB1

calcium and integrin binding 1

10519

Q99828

chr15: 90,229,975-90,234,047

PRKD2

protein kinase D2

25865

Q9BZL6

chr19: 46,674,275-46,717,127

PDGFD

platelet derived growth factor D

80310

Q9GZP0

chr11: 103,907,186-104,164,379

GLIPR2

GLI pathogenesis-related 2

152007

Q9H4G4

chr9: 36,136,536-36,163,913

GAREM1

GRB2 associated regulator of MAPK1 subtype 1

64762

Q9H706

chr18: 32,124,877-32,470,484

TRPV4

transient receptor potential cation channel, subfamily V, member 4

59341

Q9HBA0

chr12: 109,783,085-109,833,401

NOX4

NADPH oxidase 4

50507

Q9NPH5

chr11: 89,324,356-89,498,187

PDGFC

platelet derived growth factor C

56034

Q9NRA1

chr4: 156,760,454-156,971,394

DNAJC27

DnaJ heat shock protein family (Hsp40) member C27

51277

Q9NZQ0

chr2: 24,943,636-24,972,094

NDRG4

NDRG family member 4

65009

Q9ULP0

chr16: 58,462,846-58,513,628

PYCARD

PYD and CARD domain containing

29108

Q9ULZ3

chr16: 31,201,485-31,203,450

PTPN22

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

26191

Q9Y2R2

chr1: 113,813,811-113,871,759