Gene Ontology Description

GO ID GO:0046627
Ontology BP
GO Term negative regulation of insulin receptor signaling pathway
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

SOCS2

suppressor of cytokine signaling 2

8835

O14508

chr12: 93,569,814-93,583,487

SOCS3

suppressor of cytokine signaling 3

9021

O14543

chr17: 78,356,778-78,360,077

MSTN

myostatin

2660

O14793

chr2: 190,055,697-190,062,729

SOCS1

suppressor of cytokine signaling 1

8651

O15524

chr16: 11,254,405-11,256,179

IL1B

interleukin 1 beta

3553

P01584

chr2: 112,829,751-112,836,903

AHSG

alpha-2-HS-glycoprotein

197

P02765

chr3: 186,612,923-186,621,318

PRKCB

protein kinase C, beta

5579

P05771

chr16: 23,836,001-24,220,611

PTPN2

protein tyrosine phosphatase, non-receptor type 2

5771

P17706

chr18: 12,785,478-12,929,643

ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1

5167

P22413

chr6: 131,808,016-131,895,155

IRS1

insulin receptor substrate 1

3667

P35568

chr2: 226,731,317-226,799,759

TSC2

tuberous sclerosis 2

7249

P49815

chr16: 2,047,465-2,088,720

RELA

v-rel avian reticuloendotheliosis viral oncogene homolog A

5970

Q04206

chr11: 65,653,596-65,663,094

PRKCQ

protein kinase C, theta

5588

Q04759

chr10: 6,427,143-6,580,301

PRKCD

protein kinase C, delta

5580

Q05655

chr3: 53,156,009-53,192,717

GRB10

growth factor receptor bound protein 10

2887

Q13322

chr7: 50,590,063-50,793,462

KANK1

KN motif and ankyrin repeat domains 1

23189

Q14678

chr9: 470,291-746,106

PID1

phosphotyrosine interaction domain containing 1

55022

Q7Z2X4

chr2: 228,850,526-229,271,285

INPP5K

inositol polyphosphate-5-phosphatase K

51763

Q9BT40

chr17: 1,494,571-1,516,888

LMBRD1

LMBR1 domain containing 1

55788

Q9NUN5

chr6: 69,675,802-69,797,111