Gene Ontology Description

GO ID GO:0014704
Ontology CC
GO Term intercalated disc
Definition A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

OBSL1

obscurin-like 1

23363

O75147

chr2: 219,550,729-219,571,859

ATP1B1

ATPase, Na+/K+ transporting, beta 1 polypeptide

481

P05026

chr1: 169,105,697-169,132,722

ITGB1

integrin subunit beta 1

3688

P05556

chr10: 32,900,319-33,005,792

JUP

junction plakoglobin

3728

P14923

chr17: 41,754,604-41,786,931

DSP

desmoplakin

1832

P15924

chr6: 7,541,575-7,586,717

GJA1

gap junction protein alpha 1

2697

P17302

chr6: 121,435,692-121,449,727

DES

desmin

1674

P17661

chr2: 219,418,377-219,426,739

CDH2

cadherin 2, type 1, N-cadherin (neuronal)

1000

P19022

chr18: 27,950,966-28,177,446

CTNNA1

catenin alpha 1

1495

P35221

chr5: 138,610,967-138,935,034

GJA5

gap junction protein alpha 5

2702

P36382

chr1: 147,756,199-147,773,362

GJC1

gap junction protein gamma 1

10052

P36383

chr17: 44,798,448-44,830,816

ATP1A2

ATPase, Na+/K+ transporting, alpha 2 polypeptide

477

P50993

chr1: 160,115,759-160,143,591

HAMP

hepcidin antimicrobial peptide

57817

P81172

chr19: 35,280,716-35,285,143

ANK2

ankyrin 2, neuronal

287

Q01484

chr4: 112,818,109-113,383,740

DSC2

desmocollin 2

1824

Q02487

chr18: 31,058,840-31,102,415

YWHAH

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

7533

Q04917

chr22: 31,944,461-31,957,603

TJP1

tight junction protein 1

7082

Q07157

chr15: 29,699,367-29,968,865

ANK3

ankyrin 3, node of Ranvier (ankyrin G)

288

Q12955

chr10: 60,026,298-60,733,490

DLG1

discs, large homolog 1 (Drosophila)

1739

Q12959

chr3: 197,042,560-197,299,300

AKAP6

A-kinase anchoring protein 6

9472

Q13023

chr14: 32,329,273-32,837,681

CAMK2D

calcium/calmodulin-dependent protein kinase II delta

817

Q13557

chr4: 113,451,032-113,761,927

DSG2

desmoglein 2

1829

Q14126

chr18: 31,498,043-31,549,008

KCNJ11

potassium channel, inwardly rectifying subfamily J, member 11

3767

Q14654

chr11: 17,385,859-17,389,331

TMEM65

transmembrane protein 65

157378

Q6PI78

chr8: 124,306,189-124,372,692

FGF13

fibroblast growth factor 13

2258

Q92913

chrX: 138,614,731-139,222,777

PKP2

plakophilin 2

5318

Q99959

chr12: 32,790,745-32,896,840

RANGRF

RAN guanine nucleotide release factor

29098

Q9HD47

chr17: 8,288,497-8,290,092