Gene Ontology Description

GO ID GO:0010951
Ontology BP
GO Term negative regulation of endopeptidase activity
Definition Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

SPINT2

serine peptidase inhibitor, Kunitz type, 2

10653

O43291

chr19: 38,244,035-38,292,614

PAPLN

papilin, proteoglycan-like sulfated glycoprotein

89932

O95428

chr14: 73,237,497-73,274,640

PTTG1

pituitary tumor-transforming 1

9232

O95997

chr5: 160,421,822-160,428,744

SERPINC1

serpin peptidase inhibitor, clade C (antithrombin), member 1

462

P01008

chr1: 173,903,804-173,917,378

SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

5265

P01009

chr14: 94,376,747-94,390,693

SERPINA3

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

12

P01011

chr14: 94,612,377-94,624,055

AGT

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

183

P01019

chr1: 230,702,523-230,714,297

A2M

alpha-2-macroglobulin

2

P01023

chr12: 9,067,664-9,116,229

C3

complement component 3

718

P01024

chr19: 6,677,704-6,730,562

TIMP1

TIMP metallopeptidase inhibitor 1

7076

P01033

chrX: 47,582,313-47,586,789

CSTA

cystatin A

1475

P01040

chr3: 122,325,244-122,341,972

KNG1

kininogen 1

3827

P01042

chr3: 186,717,276-186,743,954

AMBP

alpha-1-microglobulin/bikunin precursor

259

P02760

chr9: 114,060,127-114,078,472

AHSG

alpha-2-HS-glycoprotein

197

P02765

chr3: 186,612,923-186,621,318

SLPI

secretory leukocyte peptidase inhibitor

6590

P03973

chr20: 45,252,239-45,254,564

VTN

vitronectin

7448

P04004

chr17: 28,367,276-28,373,091

CSTB

cystatin B

1476

P04080

chr21: 43,772,511-43,776,445

APP

amyloid beta (A4) precursor protein

351

P05067

chr21: 25,880,550-26,171,128

SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

5054

P05121

chr7: 101,127,089-101,139,266

SERPINA5

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

5104

P05154

chr14: 94,561,442-94,593,120

SERPING1

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

710

P05155

chr11: 57,597,387-57,614,853

SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

5270

P07093

chr2: 223,975,112-224,039,319

FURIN

furin (paired basic amino acid cleaving enzyme)

5045

P09958

chr15: 90,868,592-90,883,458

C4A

complement component 4A (Rodgers blood group)

720

P0C0L4

chr6: 31,982,024-32,002,681

C4B

complement component 4B (Chido blood group)

721

P0C0L5

chr6: 32,014,762-32,035,418

TFPI

tissue factor pathway inhibitor

7035

P10646

chr2: 187,464,230-187,565,760

COL6A3

collagen, type VI, alpha 3

1293

P12111

chr2: 237,324,003-237,414,375

TIMP2

TIMP metallopeptidase inhibitor 2

7077

P16035

chr17: 78,852,977-78,925,387

CAST

calpastatin

831

P20810

chr5: 96,525,267-96,779,595

ANOS1

anosmin 1

3730

P23352

chrX: 8,528,874-8,732,186

SERPINB3

serpin peptidase inhibitor, clade B (ovalbumin), member 3

6317

P29508

chr18: 63,655,197-63,661,963

PEBP1

phosphatidylethanolamine binding protein 1

5037

P30086

chr12: 118,135,858-118,145,584

SERPINB1

serpin peptidase inhibitor, clade B (ovalbumin), member 1

1992

P30740

chr6: 2,832,332-2,842,006

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

SERPINB5

serpin peptidase inhibitor, clade B (ovalbumin), member 5

5268

P36952

chr18: 63,476,761-63,505,085

SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

5176

P36955

chr17: 1,761,959-1,777,574

TFPI2

tissue factor pathway inhibitor 2

7980

P48307

chr7: 93,885,397-93,890,991

SERPINB4

serpin peptidase inhibitor, clade B (ovalbumin), member 4

6318

P48594

chr18: 63,637,259-63,644,298

SERPINB9

serpin peptidase inhibitor, clade B (ovalbumin), member 9

5272

P50453

chr6: 2,887,266-2,903,280

SERPINH1

serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

871

P50454

chr11: 75,562,056-75,572,783

COL4A3

collagen, type IV, alpha 3 (Goodpasture antigen)

1285

Q01955

chr2: 227,164,565-227,314,792

APLP2

amyloid beta (A4) precursor-like protein 2

334

Q06481

chr11: 130,069,837-130,144,811

BST2

bone marrow stromal cell antigen 2

684

Q10589

chr19: 17,402,939-17,405,648

SPP2

secreted phosphoprotein 2

6694

Q13103

chr2: 234,050,679-234,077,134

WFDC2

WAP four-disulfide core domain 2

10406

Q14508

chr20: 45,469,706-45,481,532

CARD16

caspase recruitment domain family member 16

114769

Q5EG05

chr11: 105,041,326-105,101,431

ITIH5

inter-alpha-trypsin inhibitor heavy chain family member 5

80760

Q86UX2

chr10: 7,559,270-7,666,998

WFDC3

WAP four-disulfide core domain 3

140686

Q8IUB2

chr20: 45,747,944-45,791,932

SERPINA12

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

145264

Q8IW75

chr14: 94,487,274-94,517,844

CPAMD8

C3 and PZP-like, alpha-2-macroglobulin domain containing 8

27151

Q8IZJ3

chr19: 16,892,947-17,026,815

SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

9806

Q92563

chr10: 72,059,035-72,089,032

SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

5274

Q99574

chr3: 167,735,243-167,825,568

PROL1

proline rich, lacrimal 1

58503

Q99935

chr4: 70,397,882-70,410,194

SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

50859

Q9BQ16

chr4: 166,733,384-167,234,796

LXN

latexin

56925

Q9BS40

chr3: 158,645,822-158,672,693

WFDC1

WAP four-disulfide core domain 1

58189

Q9HC57

chr16: 84,294,646-84,329,851

CRIM1

cysteine rich transmembrane BMP regulator 1 (chordin-like)

51232

Q9NZV1

chr2: 36,355,926-36,551,135

FETUB

fetuin B

26998

Q9UGM5

chr3: 186,635,969-186,653,141

SERPINB13

serpin peptidase inhibitor, clade B (ovalbumin), member 13

5275

Q9UIV8

chr18: 63,586,989-63,604,639

UCHL5

ubiquitin C-terminal hydrolase L5

51377

Q9Y5K5

chr1: 193,012,250-193,060,080