Gene Ontology Description

GO ID GO:0005578
Ontology CC
GO Term proteinaceous extracellular matrix
Definition A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

TNFRSF11B

tumor necrosis factor receptor superfamily member 11b

4982

O00300

chr8: 118,923,557-118,952,200

MATN2

matrilin 2

4147

O00339

chr8: 97,868,840-98,036,716

CHL1

cell adhesion molecule L1-like

10752

O00533

chr3: 196,596-409,417

CYR61

cysteine-rich, angiogenic inducer, 61

3491

O00622

chr1: 85,580,761-85,583,962

NCAN

neurocan

1463

O14594

chr19: 19,211,973-19,252,233

FLRT2

fibronectin leucine rich transmembrane protein 2

23768

O43155

chr14: 85,530,144-85,654,426

COCH

cochlin

1690

O43405

chr14: 30,874,514-30,895,065

CILP

cartilage intermediate layer protein

8483

O75339

chr15: 65,194,758-65,211,488

TECTA

tectorin alpha

7007

O75443

chr11: 121,101,173-121,191,493

GPC4

glypican 4

2239

O75487

chrX: 133,300,103-133,415,490

CRTAP

cartilage associated protein

10491

O75718

chr3: 33,113,979-33,147,773

WISP2

WNT1 inducible signaling pathway protein 2

8839

O76076

chr20: 44,714,844-44,728,509

ECM2

extracellular matrix protein 2, female organ and adipocyte specific

1842

O94769

chr9: 92,493,554-92,536,655

SLIT2

slit guidance ligand 2

9353

O94813

chr4: 20,253,260-20,620,561

WISP1

WNT1 inducible signaling pathway protein 1

8840

O95388

chr8: 133,191,039-133,230,344

PAPLN

papilin, proteoglycan-like sulfated glycoprotein

89932

O95428

chr14: 73,237,497-73,274,640

SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

5265

P01009

chr14: 94,376,747-94,390,693

TIMP1

TIMP metallopeptidase inhibitor 1

7076

P01033

chrX: 47,582,313-47,586,789

TGFB1

transforming growth factor beta 1

7040

P01137

chr19: 41,301,587-41,353,911

MMP1

matrix metallopeptidase 1

4312

P03956

chr11: 102,789,920-102,798,160

VWF

von Willebrand factor

7450

P04275

chr12: 5,948,874-6,124,770

ALPL

alkaline phosphatase, liver/bone/kidney

249

P05186

chr1: 21,509,372-21,578,412

MMP2

matrix metallopeptidase 2

4313

P08253

chr16: 55,389,700-55,506,691

MGP

matrix Gla protein

4256

P08493

chr12: 14,881,181-14,885,926

MMP10

matrix metallopeptidase 10

4319

P09238

chr11: 102,770,503-102,780,628

LGALS1

lectin, galactoside-binding, soluble, 1

3956

P09382

chr22: 37,675,608-37,679,806

WNT2

wingless-type MMTV integration site family member 2

7472

P09544

chr7: 117,276,631-117,323,289

HAPLN1

hyaluronan and proteoglycan link protein 1

1404

P10915

chr5: 83,637,805-83,721,613

COL6A2

collagen, type VI, alpha 2

1292

P12110

chr21: 46,098,097-46,132,849

COL6A3

collagen, type VI, alpha 3

1293

P12111

chr2: 237,324,003-237,414,375

BMP4

bone morphogenetic protein 4

652

P12644

chr14: 53,949,736-53,958,761

BMP1

bone morphogenetic protein 1

649

P13497

chr8: 22,164,736-22,212,326

VCAN

versican

1462

P13611

chr5: 83,471,465-83,582,303

MMP9

matrix metallopeptidase 9

4318

P14780

chr20: 46,008,908-46,016,561

VEGFA

vascular endothelial growth factor A

7422

P15692

chr6: 43,770,184-43,786,487

TIMP2

TIMP metallopeptidase inhibitor 2

7077

P16035

chr17: 78,852,977-78,925,387

OGN

osteoglycin

4969

P20774

chr9: 92,383,967-92,404,696

COL9A1

collagen, type IX, alpha 1

1297

P20849

chr6: 70,215,061-70,303,083

ZP3

zona pellucida glycoprotein 3 (sperm receptor)

7784

P21754

chr7: 76,397,518-76,442,071

BGN

biglycan

633

P21810

chrX: 153,494,939-153,509,554

TNXB

tenascin XB

7148

P22105

chr6: 32,041,154-32,115,334

MMP8

matrix metallopeptidase 8

4317

P22894

chr11: 102,711,795-102,727,050

FBLN1

fibulin 1

2192

P23142

chr22: 45,502,238-45,601,135

ANOS1

anosmin 1

3730

P23352

chrX: 8,528,874-8,732,186

MMP11

matrix metallopeptidase 11

4320

P24347

chr22: 23,768,226-23,784,316

COL8A2

collagen, type VIII, alpha 2

1296

P25067

chr1: 36,095,236-36,125,220

CALR

calreticulin

811

P27797

chr19: 12,938,578-12,944,489

LOX

lysyl oxidase

4015

P28300

chr5: 122,063,195-122,078,360

CTGF

connective tissue growth factor

1490

P29279

chr6: 131,948,176-131,951,373

GPC1

glypican 1

2817

P35052

chr2: 240,435,671-240,468,078

FBN1

fibrillin 1

2200

P35555

chr15: 48,408,306-48,645,849

TIMP3

TIMP metallopeptidase inhibitor 3

7078

P35625

chr22: 32,801,701-32,863,043

CHI3L1

chitinase 3 like 1

1116

P36222

chr1: 203,178,931-203,186,749

WNT5A

wingless-type MMTV integration site family member 5A

7474

P41221

chr3: 55,465,715-55,490,539

TFPI2

tissue factor pathway inhibitor 2

7980

P48307

chr7: 93,885,397-93,890,991

COMP

cartilage oligomeric matrix protein

1311

P49747

chr19: 18,782,773-18,791,314

MMP16

matrix metallopeptidase 16

4325

P51512

chr8: 88,032,009-88,328,025

LUM

lumican

4060

P51884

chr12: 91,102,629-91,111,831

CRISP3

cysteine-rich secretory protein 3

10321

P54108

chr6: 49,727,384-49,744,437

WNT3

wingless-type MMTV integration site family member 3

7473

P56703

chr17: 46,762,506-46,833,154

ADAMTS12

ADAM metallopeptidase with thrombospondin type 1 motif 12

81792

P58397

chr5: 33,523,535-33,892,192

ADAMTS20

ADAM metallopeptidase with thrombospondin type 1 motif 20

80070

P59510

chr12: 43,353,866-43,551,921

ZP1

zona pellucida glycoprotein 1

22917

P60852

chr11: 60,867,562-60,875,693

GPLD1

glycosylphosphatidylinositol specific phospholipase D1

2822

P80108

chr6: 24,424,565-24,495,205

FBLN2

fibulin 2

2199

P98095

chr3: 13,549,131-13,638,422

IL1RL1

interleukin 1 receptor-like 1

9173

Q01638

chr2: 102,311,502-102,352,037

TGFBR3

transforming growth factor beta receptor III

7049

Q03167

chr1: 91,680,343-91,906,335

COL10A1

collagen, type X, alpha 1

1300

Q03692

chr6: 116,118,923-116,158,747

COL14A1

collagen, type XIV, alpha 1

7373

Q05707

chr8: 120,059,780-120,372,036

FMOD

fibromodulin

2331

Q06828

chr1: 203,340,628-203,351,489

COL16A1

collagen, type XVI, alpha 1

1307

Q07092

chr1: 31,652,247-31,704,319

EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

2202

Q12805

chr2: 55,865,967-55,924,139

DGCR6

DiGeorge syndrome critical region gene 6

8214

Q14129

chr22: 18,906,028-18,914,238

SPARCL1

SPARC like 1

8404

Q14515

chr4: 87,473,335-87,531,061

LTBP1

latent transforming growth factor beta binding protein 1

4052

Q14766

chr2: 32,946,972-33,399,509

POSTN

periostin, osteoblast specific factor

10631

Q15063

chr13: 37,562,583-37,598,844

TGFBI

transforming growth factor beta induced

7045

Q15582

chr5: 136,028,895-136,063,818

HSD17B12

hydroxysteroid (17-beta) dehydrogenase 12

51144

Q53GQ0

chr11: 43,680,558-43,856,617

CPZ

carboxypeptidase Z

8532

Q66K79

chr4: 8,592,660-8,619,759

OLFML2A

olfactomedin like 2A

169611

Q68BL7

chr9: 124,777,158-124,814,885

CCBE1

collagen and calcium binding EGF domains 1

147372

Q6UXH8

chr18: 59,430,940-59,697,380

GLDN

gliomedin

342035

Q6ZMI3

chr15: 51,341,629-51,408,013

FBN3

fibrillin 3

84467

Q75N90

chr19: 8,065,402-8,149,846

PODN

podocan

127435

Q7Z5L7

chr1: 53,062,052-53,085,502

SBSPON

somatomedin B and thrombospondin type 1 domain containing

157869

Q8IVN8

chr8: 73,064,540-73,124,088

GPC2

glypican 2

221914

Q8N158

chr7: 100,169,606-100,177,372

SFRP1

secreted frizzled-related protein 1

6422

Q8N474

chr8: 41,261,958-41,309,497

NDNF

neuron-derived neurotrophic factor

79625

Q8TB73

chr4: 121,035,613-121,073,021

ADAMTS17

ADAM metallopeptidase with thrombospondin type 1 motif 17

170691

Q8TE56

chr15: 99,971,589-100,342,005

ADAMTS15

ADAM metallopeptidase with thrombospondin type 1 motif 15

170689

Q8TE58

chr11: 130,448,974-130,476,641

ADAMTS18

ADAM metallopeptidase with thrombospondin type 1 motif 18

170692

Q8TE60

chr16: 77,247,813-77,435,114

SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

9806

Q92563

chr10: 72,059,035-72,089,032

TNR

tenascin R

7143

Q92752

chr1: 175,315,194-175,743,770

GLG1

golgi glycoprotein 1

2734

Q92896

chr16: 74,447,427-74,607,144

WNT2B

wingless-type MMTV integration site family member 2B

7482

Q93097

chr1: 112,466,541-112,530,165

CTHRC1

collagen triple helix repeat containing 1

115908

Q96CG8

chr8: 103,371,515-103,382,997

BCAN

brevican

63827

Q96GW7

chr1: 156,641,390-156,659,532

COL21A1

collagen, type XXI, alpha 1

81578

Q96P44

chr6: 56,056,590-56,394,094

MUC4

mucin 4, cell surface associated

4585

Q99102

chr3: 195,746,765-195,812,277

MMP19

matrix metallopeptidase 19

4327

Q99542

chr12: 55,835,433-55,842,966

EPYC

epiphycan

1833

Q99645

chr12: 90,963,679-91,005,026

OMD

osteomodulin

4958

Q99983

chr9: 92,414,245-92,424,461

SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

50859

Q9BQ16

chr4: 166,733,384-167,234,796

SOST

sclerostin

50964

Q9BQB4

chr17: 43,753,731-43,758,788

SPON2

spondin 2, extracellular matrix protein

10417

Q9BUD6

chr4: 1,166,932-1,208,962

EMILIN2

elastin microfibril interfacer 2

84034

Q9BXX0

chr18: 2,847,030-2,915,993

CRISPLD2

cysteine-rich secretory protein LCCL domain containing 2

83716

Q9H0B8

chr16: 84,819,984-84,920,768

WNT5B

wingless-type MMTV integration site family member 5B

81029

Q9H1J7

chr12: 1,529,891-1,647,243

SPON1

spondin 1, extracellular matrix protein

10418

Q9HCB6

chr11: 13,962,689-14,267,884

CD248

CD248 molecule, endosialin

57124

Q9HCU0

chr11: 66,314,487-66,317,044

MMP25

matrix metallopeptidase 25

64386

Q9NPA2

chr16: 3,046,681-3,060,726

CRTAC1

cartilage acidic protein 1

55118

Q9NQ79

chr10: 97,865,000-98,030,828

MMP26

matrix metallopeptidase 26

56547

Q9NRE1

chr11: 4,704,927-4,992,429

FLRT3

fibronectin leucine rich transmembrane protein 3

23767

Q9NZU0

chr20: 14,322,988-14,337,616

FLRT1

fibronectin leucine rich transmembrane protein 1

23769

Q9NZU1

chr11: 64,103,188-64,119,173

DSPP

dentin sialophosphoprotein

1834

Q9NZW4

chr4: 87,608,529-87,616,910

ADAMTS9

ADAM metallopeptidase with thrombospondin type 1 motif 9

56999

Q9P2N4

chr3: 64,515,654-64,688,000

ADAMTS7

ADAM metallopeptidase with thrombospondin type 1 motif 7

11173

Q9UKP4

chr15: 78,759,203-78,811,431

ADAMTS6

ADAM metallopeptidase with thrombospondin type 1 motif 6

11174

Q9UKP5

chr5: 65,148,736-65,481,920

ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif 5

11096

Q9UNA0

chr21: 26,917,912-26,966,513

ADAMTS8

ADAM metallopeptidase with thrombospondin type 1 motif 8

11095

Q9UP79

chr11: 130,404,925-130,428,993

HPSE

heparanase

10855

Q9Y251

chr4: 83,292,461-83,335,153

MMP24

matrix metallopeptidase 24

10893

Q9Y5R2

chr20: 35,226,654-35,277,000

GPC6

glypican 6

10082

Q9Y625

chr13: 93,226,842-94,407,401

WNT6

wingless-type MMTV integration site family member 6

7475

Q9Y6F9

chr2: 218,859,821-218,874,233

LAMC3

laminin subunit gamma 3

10319

Q9Y6N6

chr9: 131,009,082-131,094,473