Gene Ontology Description

GO ID GO:0005088
Ontology MF
GO Term Ras guanyl-nucleotide exchange factor activity
Definition Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

EREG

epiregulin

2069

O14944

chr4: 74,365,143-74,388,751

JAK2

Janus kinase 2

3717

O60674

chr9: 4,984,390-5,128,183

FGF18

fibroblast growth factor 18

8817

O76093

chr5: 171,419,656-171,457,623

FGF19

fibroblast growth factor 19

9965

O95750

chr11: 69,698,232-69,704,642

EGFR

epidermal growth factor receptor

1956

P00533

chr7: 55,019,021-55,211,628

PDGFB

platelet-derived growth factor beta polypeptide

5155

P01127

chr22: 39,223,359-39,244,751

PDGFA

platelet-derived growth factor alpha polypeptide

5154

P04085

chr7: 497,258-520,296

ERBB2

erb-b2 receptor tyrosine kinase 2

2064

P04626

chr17: 39,687,914-39,730,426

FYN

FYN proto-oncogene, Src family tyrosine kinase

2534

P06241

chr6: 111,660,332-111,873,452

ADRB1

adrenoceptor beta 1

153

P08588

chr10: 114,044,056-114,046,908

FGF2

fibroblast growth factor 2 (basic)

2247

P09038

chr4: 122,826,708-122,898,236

PDGFRB

platelet-derived growth factor receptor, beta polypeptide

5159

P09619

chr5: 150,113,837-150,155,872

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

3815

P10721

chr4: 54,657,918-54,740,715

FGFR1

fibroblast growth factor receptor 1

2260

P11362

chr8: 38,411,138-38,468,834

NCAM1

neural cell adhesion molecule 1

4684

P13591

chr11: 112,961,247-113,278,436

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

5156

P16234

chr4: 54,229,097-54,298,247

KITLG

KIT ligand

4254

P21583

chr12: 88,492,793-88,580,851

FGF7

fibroblast growth factor 7

2252

P21781

chr15: 49,423,096-49,488,775

FGFR2

fibroblast growth factor receptor 2

2263

P21802

chr10: 121,478,334-121,598,458

ERBB3

erb-b2 receptor tyrosine kinase 3

2065

P21860

chr12: 56,079,857-56,103,505

JAK1

Janus kinase 1

3716

P23458

chr1: 64,833,229-64,966,504

FGF9

fibroblast growth factor 9

2254

P31371

chr13: 21,671,383-21,704,498

BTC

betacellulin

685

P35070

chr4: 74,744,759-74,794,686

IRS1

insulin receptor substrate 1

3667

P35568

chr2: 226,731,317-226,799,759

ACTN2

actinin, alpha 2

88

P35609

chr1: 236,686,454-236,764,631

JAK3

Janus kinase 3

3718

P52333

chr19: 17,824,780-17,848,071

CALM2

calmodulin 2

805

P62158

chr2: 47,160,082-47,176,601

GRB2

growth factor receptor bound protein 2

2885

P62993

chr17: 75,318,076-75,405,709

DLG4

discs, large homolog 4 (Drosophila)

1742

P78352

chr17: 7,189,890-7,219,702

SHC2

SHC (Src homology 2 domain containing) transforming protein 2

25759

P98077

chr19: 416,583-460,996

SPTBN1

spectrin, beta, non-erythrocytic 1

6711

Q01082

chr2: 54,456,285-54,671,445

IL5RA

interleukin 5 receptor subunit alpha

3568

Q01344

chr3: 3,066,326-3,126,613

NRG1

neuregulin 1

3084

Q02297

chr8: 31,639,386-32,767,959

TEK

TEK tyrosine kinase, endothelial

7010

Q02763

chr9: 27,109,141-27,230,175

PTK2

protein tyrosine kinase 2

5747

Q05397

chr8: 140,657,900-141,002,216

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

6654

Q07889

chr2: 38,981,396-39,124,345

GRIN2A

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

2903

Q12879

chr16: 9,753,404-10,182,754

CAMK2D

calcium/calmodulin-dependent protein kinase II delta

817

Q13557

chr4: 113,451,032-113,761,927

ERBB4

erb-b2 receptor tyrosine kinase 4

2066

Q15303

chr2: 211,375,717-212,538,841

ANGPT1

angiopoietin 1

284

Q15389

chr8: 107,249,482-107,498,055

KNDC1

kinase non-catalytic C-lobe domain (KIND) containing 1

85442

Q76NI1

chr10: 133,160,447-133,226,412

FRS2

fibroblast growth factor receptor substrate 2

10818

Q8WU20

chr12: 69,470,349-69,579,789

RAPGEF4

Rap guanine nucleotide exchange factor 4

11069

Q8WZA2

chr2: 172,735,274-173,052,893

HBEGF

heparin-binding EGF-like growth factor

1839

Q99075

chr5: 140,332,843-140,346,631

SPTBN4

spectrin, beta, non-erythrocytic 4

57731

Q9H254

chr19: 40,466,241-40,576,464

KL

klotho

9365

Q9UEF7

chr13: 33,016,433-33,066,145

IRS2

insulin receptor substrate 2

8660

Q9Y4H2

chr13: 109,752,698-109,786,568