Gene Ontology Description

GO ID GO:0000165
Ontology BP
GO Term MAPK cascade
Definition An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

PSMD11

proteasome 26S subunit, non-ATPase 11

5717

O00231

chr17: 32,444,261-32,483,318

PSMD12

proteasome 26S subunit, non-ATPase 12

5718

O00232

chr17: 67,337,916-67,366,627

EREG

epiregulin

2069

O14944

chr4: 74,365,143-74,388,751

MAPK13

mitogen-activated protein kinase 13

5603

O15264

chr6: 36,127,809-36,144,524

PSMD3

proteasome 26S subunit, non-ATPase 3

5709

O43242

chr17: 39,980,797-39,997,960

RASA4

RAS p21 protein activator 4

10156

O43374

chr7: 102,573,807-102,616,757

JAK2

Janus kinase 2

3717

O60674

chr9: 4,984,390-5,128,183

PSMD10

proteasome 26S subunit, non-ATPase 10

5716

O75832

chrX: 108,084,207-108,091,618

PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

5063

O75914

chrX: 110,944,285-111,227,361

FGF18

fibroblast growth factor 18

8817

O76093

chr5: 171,419,656-171,457,623

FGF19

fibroblast growth factor 19

9965

O95750

chr11: 69,698,232-69,704,642

EGFR

epidermal growth factor receptor

1956

P00533

chr7: 55,019,021-55,211,628

MYC

v-myc avian myelocytomatosis viral oncogene homolog

4609

P01106

chr8: 127,735,434-127,741,434

NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

4893

P01111

chr1: 114,704,469-114,716,894

KRAS

Kirsten rat sarcoma viral oncogene homolog

3845

P01116

chr12: 25,204,789-25,250,936

PDGFB

platelet-derived growth factor beta polypeptide

5155

P01127

chr22: 39,223,359-39,244,751

TGFB1

transforming growth factor beta 1

7040

P01137

chr19: 41,301,587-41,353,911

INS

insulin

3630

P01308

chr11: 2,159,779-2,161,341

TNF

tumor necrosis factor

7124

P01375

chr6: 31,575,567-31,578,336

IL1B

interleukin 1 beta

3553

P01584

chr2: 112,829,751-112,836,903

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

5894

P04049

chr3: 12,583,601-12,664,226

PDGFA

platelet-derived growth factor alpha polypeptide

5154

P04085

chr7: 497,258-520,296

ERBB2

erb-b2 receptor tyrosine kinase 2

2064

P04626

chr17: 39,687,914-39,730,426

FYN

FYN proto-oncogene, Src family tyrosine kinase

2534

P06241

chr6: 111,660,332-111,873,452

FGF2

fibroblast growth factor 2 (basic)

2247

P09038

chr4: 122,826,708-122,898,236

PDGFRB

platelet-derived growth factor receptor, beta polypeptide

5159

P09619

chr5: 150,113,837-150,155,872

UBC

ubiquitin C

7316

P0CG48

chr12: 124,911,604-124,917,368

CCL3

chemokine (C-C motif) ligand 3

6348

P10147

chr17: 36,088,256-36,090,169

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

3815

P10721

chr4: 54,657,918-54,740,715

FGFR1

fibroblast growth factor receptor 1

2260

P11362

chr8: 38,411,138-38,468,834

CCL2

chemokine (C-C motif) ligand 2

6347

P13500

chr17: 34,255,218-34,257,203

CCL5

chemokine (C-C motif) ligand 5

6352

P13501

chr17: 35,871,491-35,880,793

SCG2

secretogranin II

7857

P13521

chr2: 223,596,940-223,602,503

NCAM1

neural cell adhesion molecule 1

4684

P13591

chr11: 112,961,247-113,278,436

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

5156

P16234

chr4: 54,229,097-54,298,247

PSMC3

proteasome 26S subunit, ATPase 3

5702

P17980

chr11: 47,418,769-47,426,473

PSMB1

proteasome subunit beta 1

5689

P20618

chr6: 170,535,117-170,553,341

EFNA1

ephrin-A1

1942

P20827

chr1: 155,127,460-155,134,857

RASA1

RAS p21 protein activator (GTPase activating protein) 1

5921

P20936

chr5: 87,267,888-87,391,931

KITLG

KIT ligand

4254

P21583

chr12: 88,492,793-88,580,851

FGF7

fibroblast growth factor 7

2252

P21781

chr15: 49,423,096-49,488,775

FGFR2

fibroblast growth factor receptor 2

2263

P21802

chr10: 121,478,334-121,598,458

ERBB3

erb-b2 receptor tyrosine kinase 3

2065

P21860

chr12: 56,079,857-56,103,505

JAK1

Janus kinase 1

3716

P23458

chr1: 64,833,229-64,966,504

PSMA1

proteasome subunit alpha 1

5682

P25786

chr11: 14,504,874-14,643,635

PSMA2

proteasome subunit alpha 2

5683

P25787

chr7: 42,916,857-42,932,223

PSMA3

proteasome subunit alpha 3

5684

P25788

chr14: 58,244,831-58,272,012

PSMA4

proteasome subunit alpha 4

5685

P25789

chr15: 78,540,405-78,552,419

ZFP36

ZFP36 ring finger protein

7538

P26651

chr19: 39,406,813-39,409,412

MAPK3

mitogen-activated protein kinase 3

5595

P27361

chr16: 30,114,105-30,123,506

PSMB8

proteasome subunit beta 8

5696

P28062

chr6: 32,840,717-32,844,703

PSMB9

proteasome subunit beta 9

5698

P28065

chr6: 32,844,136-32,859,585

PSMB4

proteasome subunit beta 4

5692

P28070

chr1: 151,399,534-151,401,944

PSMB5

proteasome subunit beta 5

5693

P28074

chr14: 23,016,543-23,035,230

MAPK1

mitogen-activated protein kinase 1

5594

P28482

chr22: 21,754,500-21,867,680

PEBP1

phosphatidylethanolamine binding protein 1

5037

P30086

chr12: 118,135,858-118,145,584

FGF9

fibroblast growth factor 9

2254

P31371

chr13: 21,671,383-21,704,498

YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

7529

P31946

chr20: 44,885,676-44,908,532

BTC

betacellulin

685

P35070

chr4: 74,744,759-74,794,686

IRS1

insulin receptor substrate 1

3667

P35568

chr2: 226,731,317-226,799,759

ACTN2

actinin, alpha 2

88

P35609

chr1: 236,686,454-236,764,631

PSMC2

proteasome 26S subunit, ATPase 2

5701

P35998

chr7: 103,344,254-103,369,395

MAP2K2

mitogen-activated protein kinase kinase 2

5605

P36507

chr19: 4,090,321-4,124,129

PSMB10

proteasome subunit beta 10

5699

P40306

chr16: 67,934,502-67,937,087

PSMC4

proteasome 26S subunit, ATPase 4

5704

P43686

chr19: 39,971,005-39,981,441

MAPKAPK2

mitogen-activated protein kinase-activated protein kinase 2

9261

P49137

chr1: 206,684,944-206,734,283

PSMB3

proteasome subunit beta 3

5691

P49720

chr17: 38,752,736-38,764,231

PSMD7

proteasome 26S subunit, non-ATPase 7

5713

P51665

chr16: 74,296,775-74,306,288

JAK3

Janus kinase 3

3718

P52333

chr19: 17,824,780-17,848,071

MAP2K6

mitogen-activated protein kinase kinase 6

5608

P52564

chr17: 69,414,698-69,543,331

NDST1

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

3340

P52848

chr5: 150,485,818-150,558,211

MAP3K7CL

MAP3K7 C-terminal like

56911

P57077

chr21: 29,077,471-29,175,889

PSME3

proteasome activator subunit 3

10197

P61289

chr17: 42,824,385-42,843,758

CALM2

calmodulin 2

805

P62158

chr2: 47,160,082-47,176,601

PSMC1

proteasome 26S subunit, ATPase 1

5700

P62191

chr14: 90,256,495-90,275,429

PSMC6

proteasome 26S subunit, ATPase 6

5706

P62333

chr14: 52,707,172-52,728,587

RBX1

ring-box 1, E3 ubiquitin protein ligase

9978

P62877

chr22: 40,951,347-40,973,309

RPS27A

ribosomal protein S27a

6233

P62979

chr2: 55,231,903-55,235,853

UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

7311

P62987

chr19: 18,571,730-18,577,550

GRB2

growth factor receptor bound protein 2

2885

P62993

chr17: 75,318,076-75,405,709

DLG4

discs, large homolog 4 (Drosophila)

1742

P78352

chr17: 7,189,890-7,219,702

SHC2

SHC (Src homology 2 domain containing) transforming protein 2

25759

P98077

chr19: 416,583-460,996

SPTBN1

spectrin, beta, non-erythrocytic 1

6711

Q01082

chr2: 54,456,285-54,671,445

IL5RA

interleukin 5 receptor subunit alpha

3568

Q01344

chr3: 3,066,326-3,126,613

MEF2A

myocyte enhancer factor 2A

4205

Q02078

chr15: 99,565,417-99,716,466

NRG1

neuregulin 1

3084

Q02297

chr8: 31,639,386-32,767,959

MAP2K1

mitogen-activated protein kinase kinase 1

5604

Q02750

chr15: 66,386,817-66,492,312

TEK

TEK tyrosine kinase, endothelial

7010

Q02763

chr9: 27,109,141-27,230,175

CAV1

caveolin 1

857

Q03135

chr7: 116,524,785-116,561,184

PTK2

protein tyrosine kinase 2

5747

Q05397

chr8: 140,657,900-141,002,216

MEF2C

myocyte enhancer factor 2C

4208

Q06413

chr5: 88,717,117-88,904,257

ZFP36L1

ZFP36 ring finger protein-like 1

677

Q07352

chr14: 68,787,660-68,796,253

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

6654

Q07889

chr2: 38,981,396-39,124,345

GRIN2A

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

2903

Q12879

chr16: 9,753,404-10,182,754

MAPK7

mitogen-activated protein kinase 7

5598

Q13164

chr17: 19,377,721-19,383,544

PSMD2

proteasome 26S subunit, non-ATPase 2

5708

Q13200

chr3: 184,298,709-184,309,054

CAMK2D

calcium/calmodulin-dependent protein kinase II delta

817

Q13557

chr4: 113,451,032-113,761,927

CUL3

cullin 3

8452

Q13618

chr2: 224,470,150-224,585,397

IL18

interleukin 18

3606

Q14116

chr11: 112,143,251-112,164,117

RASA3

RAS p21 protein activator 3

22821

Q14644

chr13: 113,977,783-114,132,611

MEF2D

myocyte enhancer factor 2D

4209

Q14814

chr1: 156,463,727-156,500,828

PSME4

proteasome activator subunit 4

23198

Q14997

chr2: 53,864,067-53,970,840

PEA15

phosphoprotein enriched in astrocytes 15

8682

Q15121

chr1: 160,205,337-160,215,376

RASA2

RAS p21 protein activator 2

5922

Q15283

chr3: 141,487,047-141,615,342

ERBB4

erb-b2 receptor tyrosine kinase 4

2066

Q15303

chr2: 211,375,717-212,538,841

ANGPT1

angiopoietin 1

284

Q15389

chr8: 107,249,482-107,498,055

SMAD1

SMAD family member 1

4086

Q15797

chr4: 145,481,194-145,558,079

DUSP5

dual specificity phosphatase 5

1847

Q16690

chr10: 110,497,838-110,511,544

DUSP6

dual specificity phosphatase 6

1848

Q16828

chr12: 89,347,232-89,353,271

DUSP7

dual specificity phosphatase 7

1849

Q16829

chr3: 52,048,919-52,056,550

SETX

senataxin

23064

Q7Z333

chr9: 132,261,356-132,354,985

SPRED1

sprouty-related, EVH1 domain containing 1

161742

Q7Z699

chr15: 38,252,326-38,357,249

PABPN1

poly(A) binding protein, nuclear 1

8106

Q86U42

chr14: 23,321,289-23,326,185

FRS2

fibroblast growth factor receptor substrate 2

10818

Q8WU20

chr12: 69,470,349-69,579,789

FGF13

fibroblast growth factor 13

2258

Q92913

chrX: 138,614,731-139,222,777

SYNGAP1

synaptic Ras GTPase activating protein 1

8831

Q96PV0

chr6: 33,419,661-33,457,541

HBEGF

heparin-binding EGF-like growth factor

1839

Q99075

chr5: 140,332,843-140,346,631

MAP3K5

mitogen-activated protein kinase kinase kinase 5

4217

Q99683

chr6: 136,557,047-136,792,518

DUSP9

dual specificity phosphatase 9

1852

Q99956

chrX: 153,642,492-153,651,326

SPTBN4

spectrin, beta, non-erythrocytic 4

57731

Q9H254

chr19: 40,466,241-40,576,464

TAOK3

TAO kinase 3

51347

Q9H2K8

chr12: 118,149,801-118,372,945

DOK5

docking protein 5

55816

Q9P104

chr20: 54,475,597-54,651,171

NLK

nemo-like kinase

51701

Q9UBE8

chr17: 28,041,737-28,196,381

KL

klotho

9365

Q9UEF7

chr13: 33,016,433-33,066,145

LAMTOR3

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

8649

Q9UHA4

chr4: 99,878,336-99,894,490

LAMTOR2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

28956

Q9Y2Q5

chr1: 156,054,752-156,058,510

IRS2

insulin receptor substrate 2

8660

Q9Y4H2

chr13: 109,752,698-109,786,568

MAP3K4

mitogen-activated protein kinase kinase kinase 4

4216

Q9Y6R4

chr6: 160,991,727-161,117,385