| GO ID | GO:0000165 |
| Ontology | BP |
| GO Term | MAPK cascade |
| Definition | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| Gene Symbol | Description | Entrez ID | Uniprot ID | Chromosomal Location |
|---|---|---|---|---|
|
PSMD11 |
proteasome 26S subunit, non-ATPase 11 |
5717 |
O00231 |
chr17: 32,444,261-32,483,318 |
|
PSMD12 |
proteasome 26S subunit, non-ATPase 12 |
5718 |
O00232 |
chr17: 67,337,916-67,366,627 |
|
EREG |
epiregulin |
2069 |
O14944 |
chr4: 74,365,143-74,388,751 |
|
MAPK13 |
mitogen-activated protein kinase 13 |
5603 |
O15264 |
chr6: 36,127,809-36,144,524 |
|
PSMD3 |
proteasome 26S subunit, non-ATPase 3 |
5709 |
O43242 |
chr17: 39,980,797-39,997,960 |
|
RASA4 |
RAS p21 protein activator 4 |
10156 |
O43374 |
chr7: 102,573,807-102,616,757 |
|
JAK2 |
Janus kinase 2 |
3717 |
O60674 |
chr9: 4,984,390-5,128,183 |
|
PSMD10 |
proteasome 26S subunit, non-ATPase 10 |
5716 |
O75832 |
chrX: 108,084,207-108,091,618 |
|
PAK3 |
p21 protein (Cdc42/Rac)-activated kinase 3 |
5063 |
O75914 |
chrX: 110,944,285-111,227,361 |
|
FGF18 |
fibroblast growth factor 18 |
8817 |
O76093 |
chr5: 171,419,656-171,457,623 |
|
FGF19 |
fibroblast growth factor 19 |
9965 |
O95750 |
chr11: 69,698,232-69,704,642 |
|
EGFR |
epidermal growth factor receptor |
1956 |
P00533 |
chr7: 55,019,021-55,211,628 |
|
MYC |
v-myc avian myelocytomatosis viral oncogene homolog |
4609 |
P01106 |
chr8: 127,735,434-127,741,434 |
|
NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
4893 |
P01111 |
chr1: 114,704,469-114,716,894 |
|
KRAS |
Kirsten rat sarcoma viral oncogene homolog |
3845 |
P01116 |
chr12: 25,204,789-25,250,936 |
|
PDGFB |
platelet-derived growth factor beta polypeptide |
5155 |
P01127 |
chr22: 39,223,359-39,244,751 |
|
TGFB1 |
transforming growth factor beta 1 |
7040 |
P01137 |
chr19: 41,301,587-41,353,911 |
|
INS |
insulin |
3630 |
P01308 |
chr11: 2,159,779-2,161,341 |
|
TNF |
tumor necrosis factor |
7124 |
P01375 |
chr6: 31,575,567-31,578,336 |
|
IL1B |
interleukin 1 beta |
3553 |
P01584 |
chr2: 112,829,751-112,836,903 |
|
RAF1 |
Raf-1 proto-oncogene, serine/threonine kinase |
5894 |
P04049 |
chr3: 12,583,601-12,664,226 |
|
PDGFA |
platelet-derived growth factor alpha polypeptide |
5154 |
P04085 |
chr7: 497,258-520,296 |
|
ERBB2 |
erb-b2 receptor tyrosine kinase 2 |
2064 |
P04626 |
chr17: 39,687,914-39,730,426 |
|
FYN |
FYN proto-oncogene, Src family tyrosine kinase |
2534 |
P06241 |
chr6: 111,660,332-111,873,452 |
|
FGF2 |
fibroblast growth factor 2 (basic) |
2247 |
P09038 |
chr4: 122,826,708-122,898,236 |
|
PDGFRB |
platelet-derived growth factor receptor, beta polypeptide |
5159 |
P09619 |
chr5: 150,113,837-150,155,872 |
|
UBC |
ubiquitin C |
7316 |
P0CG48 |
chr12: 124,911,604-124,917,368 |
|
CCL3 |
chemokine (C-C motif) ligand 3 |
6348 |
P10147 |
chr17: 36,088,256-36,090,169 |
|
KIT |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
3815 |
P10721 |
chr4: 54,657,918-54,740,715 |
|
FGFR1 |
fibroblast growth factor receptor 1 |
2260 |
P11362 |
chr8: 38,411,138-38,468,834 |
|
CCL2 |
chemokine (C-C motif) ligand 2 |
6347 |
P13500 |
chr17: 34,255,218-34,257,203 |
|
CCL5 |
chemokine (C-C motif) ligand 5 |
6352 |
P13501 |
chr17: 35,871,491-35,880,793 |
|
SCG2 |
secretogranin II |
7857 |
P13521 |
chr2: 223,596,940-223,602,503 |
|
NCAM1 |
neural cell adhesion molecule 1 |
4684 |
P13591 |
chr11: 112,961,247-113,278,436 |
|
PDGFRA |
platelet-derived growth factor receptor, alpha polypeptide |
5156 |
P16234 |
chr4: 54,229,097-54,298,247 |
|
PSMC3 |
proteasome 26S subunit, ATPase 3 |
5702 |
P17980 |
chr11: 47,418,769-47,426,473 |
|
PSMB1 |
proteasome subunit beta 1 |
5689 |
P20618 |
chr6: 170,535,117-170,553,341 |
|
EFNA1 |
ephrin-A1 |
1942 |
P20827 |
chr1: 155,127,460-155,134,857 |
|
RASA1 |
RAS p21 protein activator (GTPase activating protein) 1 |
5921 |
P20936 |
chr5: 87,267,888-87,391,931 |
|
KITLG |
KIT ligand |
4254 |
P21583 |
chr12: 88,492,793-88,580,851 |
|
FGF7 |
fibroblast growth factor 7 |
2252 |
P21781 |
chr15: 49,423,096-49,488,775 |
|
FGFR2 |
fibroblast growth factor receptor 2 |
2263 |
P21802 |
chr10: 121,478,334-121,598,458 |
|
ERBB3 |
erb-b2 receptor tyrosine kinase 3 |
2065 |
P21860 |
chr12: 56,079,857-56,103,505 |
|
JAK1 |
Janus kinase 1 |
3716 |
P23458 |
chr1: 64,833,229-64,966,504 |
|
PSMA1 |
proteasome subunit alpha 1 |
5682 |
P25786 |
chr11: 14,504,874-14,643,635 |
|
PSMA2 |
proteasome subunit alpha 2 |
5683 |
P25787 |
chr7: 42,916,857-42,932,223 |
|
PSMA3 |
proteasome subunit alpha 3 |
5684 |
P25788 |
chr14: 58,244,831-58,272,012 |
|
PSMA4 |
proteasome subunit alpha 4 |
5685 |
P25789 |
chr15: 78,540,405-78,552,419 |
|
ZFP36 |
ZFP36 ring finger protein |
7538 |
P26651 |
chr19: 39,406,813-39,409,412 |
|
MAPK3 |
mitogen-activated protein kinase 3 |
5595 |
P27361 |
chr16: 30,114,105-30,123,506 |
|
PSMB8 |
proteasome subunit beta 8 |
5696 |
P28062 |
chr6: 32,840,717-32,844,703 |
|
PSMB9 |
proteasome subunit beta 9 |
5698 |
P28065 |
chr6: 32,844,136-32,859,585 |
|
PSMB4 |
proteasome subunit beta 4 |
5692 |
P28070 |
chr1: 151,399,534-151,401,944 |
|
PSMB5 |
proteasome subunit beta 5 |
5693 |
P28074 |
chr14: 23,016,543-23,035,230 |
|
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
P28482 |
chr22: 21,754,500-21,867,680 |
|
PEBP1 |
phosphatidylethanolamine binding protein 1 |
5037 |
P30086 |
chr12: 118,135,858-118,145,584 |
|
FGF9 |
fibroblast growth factor 9 |
2254 |
P31371 |
chr13: 21,671,383-21,704,498 |
|
YWHAB |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
7529 |
P31946 |
chr20: 44,885,676-44,908,532 |
|
BTC |
betacellulin |
685 |
P35070 |
chr4: 74,744,759-74,794,686 |
|
IRS1 |
insulin receptor substrate 1 |
3667 |
P35568 |
chr2: 226,731,317-226,799,759 |
|
ACTN2 |
actinin, alpha 2 |
88 |
P35609 |
chr1: 236,686,454-236,764,631 |
|
PSMC2 |
proteasome 26S subunit, ATPase 2 |
5701 |
P35998 |
chr7: 103,344,254-103,369,395 |
|
MAP2K2 |
mitogen-activated protein kinase kinase 2 |
5605 |
P36507 |
chr19: 4,090,321-4,124,129 |
|
PSMB10 |
proteasome subunit beta 10 |
5699 |
P40306 |
chr16: 67,934,502-67,937,087 |
|
PSMC4 |
proteasome 26S subunit, ATPase 4 |
5704 |
P43686 |
chr19: 39,971,005-39,981,441 |
|
MAPKAPK2 |
mitogen-activated protein kinase-activated protein kinase 2 |
9261 |
P49137 |
chr1: 206,684,944-206,734,283 |
|
PSMB3 |
proteasome subunit beta 3 |
5691 |
P49720 |
chr17: 38,752,736-38,764,231 |
|
PSMD7 |
proteasome 26S subunit, non-ATPase 7 |
5713 |
P51665 |
chr16: 74,296,775-74,306,288 |
|
JAK3 |
Janus kinase 3 |
3718 |
P52333 |
chr19: 17,824,780-17,848,071 |
|
MAP2K6 |
mitogen-activated protein kinase kinase 6 |
5608 |
P52564 |
chr17: 69,414,698-69,543,331 |
|
NDST1 |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 |
3340 |
P52848 |
chr5: 150,485,818-150,558,211 |
|
MAP3K7CL |
MAP3K7 C-terminal like |
56911 |
P57077 |
chr21: 29,077,471-29,175,889 |
|
PSME3 |
proteasome activator subunit 3 |
10197 |
P61289 |
chr17: 42,824,385-42,843,758 |
|
CALM2 |
calmodulin 2 |
805 |
P62158 |
chr2: 47,160,082-47,176,601 |
|
PSMC1 |
proteasome 26S subunit, ATPase 1 |
5700 |
P62191 |
chr14: 90,256,495-90,275,429 |
|
PSMC6 |
proteasome 26S subunit, ATPase 6 |
5706 |
P62333 |
chr14: 52,707,172-52,728,587 |
|
RBX1 |
ring-box 1, E3 ubiquitin protein ligase |
9978 |
P62877 |
chr22: 40,951,347-40,973,309 |
|
RPS27A |
ribosomal protein S27a |
6233 |
P62979 |
chr2: 55,231,903-55,235,853 |
|
UBA52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
7311 |
P62987 |
chr19: 18,571,730-18,577,550 |
|
GRB2 |
growth factor receptor bound protein 2 |
2885 |
P62993 |
chr17: 75,318,076-75,405,709 |
|
DLG4 |
discs, large homolog 4 (Drosophila) |
1742 |
P78352 |
chr17: 7,189,890-7,219,702 |
|
SHC2 |
SHC (Src homology 2 domain containing) transforming protein 2 |
25759 |
P98077 |
chr19: 416,583-460,996 |
|
SPTBN1 |
spectrin, beta, non-erythrocytic 1 |
6711 |
Q01082 |
chr2: 54,456,285-54,671,445 |
|
IL5RA |
interleukin 5 receptor subunit alpha |
3568 |
Q01344 |
chr3: 3,066,326-3,126,613 |
|
MEF2A |
myocyte enhancer factor 2A |
4205 |
Q02078 |
chr15: 99,565,417-99,716,466 |
|
NRG1 |
neuregulin 1 |
3084 |
Q02297 |
chr8: 31,639,386-32,767,959 |
|
MAP2K1 |
mitogen-activated protein kinase kinase 1 |
5604 |
Q02750 |
chr15: 66,386,817-66,492,312 |
|
TEK |
TEK tyrosine kinase, endothelial |
7010 |
Q02763 |
chr9: 27,109,141-27,230,175 |
|
CAV1 |
caveolin 1 |
857 |
Q03135 |
chr7: 116,524,785-116,561,184 |
|
PTK2 |
protein tyrosine kinase 2 |
5747 |
Q05397 |
chr8: 140,657,900-141,002,216 |
|
MEF2C |
myocyte enhancer factor 2C |
4208 |
Q06413 |
chr5: 88,717,117-88,904,257 |
|
ZFP36L1 |
ZFP36 ring finger protein-like 1 |
677 |
Q07352 |
chr14: 68,787,660-68,796,253 |
|
SOS1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
6654 |
Q07889 |
chr2: 38,981,396-39,124,345 |
|
GRIN2A |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
2903 |
Q12879 |
chr16: 9,753,404-10,182,754 |
|
MAPK7 |
mitogen-activated protein kinase 7 |
5598 |
Q13164 |
chr17: 19,377,721-19,383,544 |
|
PSMD2 |
proteasome 26S subunit, non-ATPase 2 |
5708 |
Q13200 |
chr3: 184,298,709-184,309,054 |
|
CAMK2D |
calcium/calmodulin-dependent protein kinase II delta |
817 |
Q13557 |
chr4: 113,451,032-113,761,927 |
|
CUL3 |
cullin 3 |
8452 |
Q13618 |
chr2: 224,470,150-224,585,397 |
|
IL18 |
interleukin 18 |
3606 |
Q14116 |
chr11: 112,143,251-112,164,117 |
|
RASA3 |
RAS p21 protein activator 3 |
22821 |
Q14644 |
chr13: 113,977,783-114,132,611 |
|
MEF2D |
myocyte enhancer factor 2D |
4209 |
Q14814 |
chr1: 156,463,727-156,500,828 |
|
PSME4 |
proteasome activator subunit 4 |
23198 |
Q14997 |
chr2: 53,864,067-53,970,840 |
|
PEA15 |
phosphoprotein enriched in astrocytes 15 |
8682 |
Q15121 |
chr1: 160,205,337-160,215,376 |
|
RASA2 |
RAS p21 protein activator 2 |
5922 |
Q15283 |
chr3: 141,487,047-141,615,342 |
|
ERBB4 |
erb-b2 receptor tyrosine kinase 4 |
2066 |
Q15303 |
chr2: 211,375,717-212,538,841 |
|
ANGPT1 |
angiopoietin 1 |
284 |
Q15389 |
chr8: 107,249,482-107,498,055 |
|
SMAD1 |
SMAD family member 1 |
4086 |
Q15797 |
chr4: 145,481,194-145,558,079 |
|
DUSP5 |
dual specificity phosphatase 5 |
1847 |
Q16690 |
chr10: 110,497,838-110,511,544 |
|
DUSP6 |
dual specificity phosphatase 6 |
1848 |
Q16828 |
chr12: 89,347,232-89,353,271 |
|
DUSP7 |
dual specificity phosphatase 7 |
1849 |
Q16829 |
chr3: 52,048,919-52,056,550 |
|
SETX |
senataxin |
23064 |
Q7Z333 |
chr9: 132,261,356-132,354,985 |
|
SPRED1 |
sprouty-related, EVH1 domain containing 1 |
161742 |
Q7Z699 |
chr15: 38,252,326-38,357,249 |
|
PABPN1 |
poly(A) binding protein, nuclear 1 |
8106 |
Q86U42 |
chr14: 23,321,289-23,326,185 |
|
FRS2 |
fibroblast growth factor receptor substrate 2 |
10818 |
Q8WU20 |
chr12: 69,470,349-69,579,789 |
|
FGF13 |
fibroblast growth factor 13 |
2258 |
Q92913 |
chrX: 138,614,731-139,222,777 |
|
SYNGAP1 |
synaptic Ras GTPase activating protein 1 |
8831 |
Q96PV0 |
chr6: 33,419,661-33,457,541 |
|
HBEGF |
heparin-binding EGF-like growth factor |
1839 |
Q99075 |
chr5: 140,332,843-140,346,631 |
|
MAP3K5 |
mitogen-activated protein kinase kinase kinase 5 |
4217 |
Q99683 |
chr6: 136,557,047-136,792,518 |
|
DUSP9 |
dual specificity phosphatase 9 |
1852 |
Q99956 |
chrX: 153,642,492-153,651,326 |
|
SPTBN4 |
spectrin, beta, non-erythrocytic 4 |
57731 |
Q9H254 |
chr19: 40,466,241-40,576,464 |
|
TAOK3 |
TAO kinase 3 |
51347 |
Q9H2K8 |
chr12: 118,149,801-118,372,945 |
|
DOK5 |
docking protein 5 |
55816 |
Q9P104 |
chr20: 54,475,597-54,651,171 |
|
NLK |
nemo-like kinase |
51701 |
Q9UBE8 |
chr17: 28,041,737-28,196,381 |
|
KL |
klotho |
9365 |
Q9UEF7 |
chr13: 33,016,433-33,066,145 |
|
LAMTOR3 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
8649 |
Q9UHA4 |
chr4: 99,878,336-99,894,490 |
|
LAMTOR2 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 |
28956 |
Q9Y2Q5 |
chr1: 156,054,752-156,058,510 |
|
IRS2 |
insulin receptor substrate 2 |
8660 |
Q9Y4H2 |
chr13: 109,752,698-109,786,568 |
|
MAP3K4 |
mitogen-activated protein kinase kinase kinase 4 |
4216 |
Q9Y6R4 |
chr6: 160,991,727-161,117,385 |