Domain Description

Interpro ID IPR001849
Name PH_domain
Description Pleckstrin homology domain
Cross References PF00169, PF16457, PF16652, PS50003, SM00233
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

ARHGAP42

Rho GTPase activating protein 42

143872

A6NI28

chr11: 100,687,653-100,991,937

IRS4

insulin receptor substrate 4

8471

O14654

chrX: 108,732,482-108,736,409

ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

8853

O43150

chr2: 9,206,765-9,405,683

RASA4

RAS p21 protein activator 4

10156

O43374

chr7: 102,573,807-102,616,757

CYTH3

cytohesin 3

9265

O43739

chr7: 6,161,776-6,272,644

KIF1B

kinesin family member 1B

23095

O60333

chr1: 10,210,805-10,381,603

ROCK2

Rho-associated, coiled-coil containing protein kinase 2

9475

O75116

chr2: 11,179,761-11,348,330

SKAP2

src kinase associated phosphoprotein 2

8935

O75563

chr7: 26,667,062-26,995,239

ADAP1

ArfGAP with dual PH domains 1

11033

O75689

chr7: 897,901-955,407

PLEKHG5

pleckstrin homology and RhoGEF domain containing G5

57449

O94827

chr1: 6,466,092-6,520,061

FARP2

FERM, ARH/RhoGEF and pleckstrin domain protein 2

9855

O94887

chr2: 241,356,243-241,494,841

SBF1

SET binding factor 1

6305

O95248

chr22: 50,445,000-50,475,024

BCR

breakpoint cluster region

613

P11274

chr22: 23,179,704-23,318,037

VAV1

vav guanine nucleotide exchange factor 1

7409

P15498

chr19: 6,772,714-6,857,366

PLCG2

phospholipase C gamma 2

5336

P16885

chr16: 81,739,097-81,962,693

RASA1

RAS p21 protein activator (GTPase activating protein) 1

5921

P20936

chr5: 87,267,888-87,391,931

OSBP

oxysterol binding protein

5007

P22059

chr11: 59,574,398-59,616,144

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

AKT2

v-akt murine thymoma viral oncogene homolog 2

208

P31751

chr19: 40,230,317-40,285,536

IRS1

insulin receptor substrate 1

3667

P35568

chr2: 226,731,317-226,799,759

ADRBK2

adrenergic, beta, receptor kinase 2

157

P35626

chr22: 25,564,849-25,729,294

ARHGAP25

Rho GTPase activating protein 25

9938

P42331

chr2: 68,679,601-68,826,833

PLCD1

phospholipase C delta 1

5333

P51178

chr3: 38,007,496-38,029,762

SPTBN1

spectrin, beta, non-erythrocytic 1

6711

Q01082

chr2: 54,456,285-54,671,445

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

6654

Q07889

chr2: 38,981,396-39,124,345

SOS2

SOS Ras/Rho guanine nucleotide exchange factor 2

6655

Q07890

chr14: 50,117,120-50,231,558

ARHGEF5

Rho guanine nucleotide exchange factor 5

7984

Q12774

chr7: 144,355,288-144,380,632

AKAP13

A-kinase anchoring protein 13

11214

Q12802

chr15: 85,380,571-85,749,358

ABR

active BCR-related

29

Q12979

chr17: 1,003,518-1,229,021

TIAM1

T-cell lymphoma invasion and metastasis 1

7074

Q13009

chr21: 31,118,416-31,559,977

GRB10

growth factor receptor bound protein 10

2887

Q13322

chr7: 50,590,063-50,793,462

PLD1

phospholipase D1

5337

Q13393

chr3: 171,600,405-171,810,950

SNTA1

syntrophin, alpha 1

6640

Q13424

chr20: 33,407,955-33,443,892

SNTB2

syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)

6645

Q13425

chr16: 69,187,129-69,309,052

GAB1

GRB2 associated binding protein 1

2549

Q13480

chr4: 143,336,762-143,474,568

SNTB1

syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)

6641

Q13884

chr8: 120,535,745-120,813,273

ARHGEF7

Rho guanine nucleotide exchange factor 7

8874

Q14155

chr13: 111,114,559-111,305,737

GRB14

growth factor receptor bound protein 14

2888

Q14449

chr2: 164,492,812-164,621,848

RASA3

RAS p21 protein activator 3

22821

Q14644

chr13: 113,977,783-114,132,611

ACAP2

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

23527

Q15057

chr3: 195,274,736-195,443,078

PLCL1

phospholipase C like 1

5334

Q15111

chr2: 197,804,702-198,572,581

PRKD1

protein kinase D1

5587

Q15139

chr14: 29,576,479-30,191,898

RASA2

RAS p21 protein activator 2

5922

Q15283

chr3: 141,487,047-141,615,342

ITSN1

intersectin 1

6453

Q15811

chr21: 33,642,400-33,899,861

PHLDA2

pleckstrin homology-like domain, family A, member 2

7262

Q53GA4

chr11: 2,928,273-2,929,455

PLEKHO1

pleckstrin homology domain containing O1

51177

Q53GL0

chr1: 150,149,183-150,164,720

RALGPS1

Ral GEF with PH domain and SH3 binding motif 1

9649

Q5JS13

chr9: 126,914,774-127,223,166

DOCK11

dedicator of cytokinesis 11

139818

Q5JSL3

chrX: 118,495,898-118,686,163

DGKK

diacylglycerol kinase, kappa

139189

Q5KSL6

chrX: 50,365,409-50,470,738

PLEKHS1

pleckstrin homology domain containing S1

79949

Q5SXH7

chr10: 113,751,454-113,783,429

ARHGAP21

Rho GTPase activating protein 21

57584

Q5T5U3

chr10: 24,583,609-24,723,668

CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

8476

Q5VT25

chr1: 226,989,865-227,318,474

ARHGEF16

Rho guanine nucleotide exchange factor 16

27237

Q5VV41

chr1: 3,454,426-3,481,113

IQSEC1

IQ motif and Sec7 domain 1

9922

Q6DN90

chr3: 12,897,220-13,073,117

PHLDB3

pleckstrin homology-like domain, family B, member 3

653583

Q6NSJ2

chr19: 43,474,954-43,504,935

MPRIP

myosin phosphatase Rho interacting protein

23164

Q6WCQ1

chr17: 17,042,545-17,217,679

FGD6

FYVE, RhoGEF and PH domain containing 6

55785

Q6ZV73

chr12: 95,076,749-95,217,482

RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

65059

Q70E73

chr2: 203,394,345-203,535,410

PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

80243

Q70Z35

chr8: 67,952,118-68,237,030

ARHGAP22

Rho GTPase activating protein 22

58504

Q7Z5H3

chr10: 48,446,034-48,656,265

NET1

neuroepithelial cell transforming 1

10276

Q7Z628

chr10: 5,412,551-5,458,463

FGD2

FYVE, RhoGEF and PH domain containing 2

221472

Q7Z6J4

chr6: 37,005,646-37,029,070

PHLDB2

pleckstrin homology-like domain, family B, member 2

90102

Q86SQ0

chr3: 111,732,497-111,976,517

PHLDB1

pleckstrin homology-like domain, family B, member 1

23187

Q86UU1

chr11: 118,606,440-118,658,038

RALGPS2

Ral GEF with PH domain and SH3 binding motif 2

55103

Q86X27

chr1: 178,725,147-178,921,841

DGKH

diacylglycerol kinase, eta

160851

Q86XP1

chr13: 42,040,036-42,256,578

MCF2L2

MCF.2 cell line derived transforming sequence-like 2

23101

Q86YR7

chr3: 183,178,043-183,428,778

PLEKHH2

pleckstrin homology, MyTH4 and FERM domain containing H2

130271

Q8IVE3

chr2: 43,637,273-43,767,987

RTKN2

rhotekin 2

219790

Q8IZC4

chr10: 62,183,035-62,268,707

ARHGEF28

Rho guanine nucleotide exchange factor 28

64283

Q8N1W1

chr5: 73,626,158-73,941,993

ARHGAP24

Rho GTPase activating protein 24

83478

Q8N264

chr4: 85,475,114-86,002,670

ARHGEF39

Rho guanine nucleotide exchange factor 39

84904

Q8N4T4

chr9: 35,658,875-35,675,866

AFAP1L2

actin filament associated protein 1 like 2

84632

Q8N4X5

chr10: 114,294,824-114,404,756

APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

55198

Q8NEU8

chr12: 105,173,296-105,236,238

PHLDA1

pleckstrin homology-like domain, family A, member 1

22822

Q8WV24

chr12: 76,025,447-76,033,932

ARAP3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

64411

Q8WWN8

chr5: 141,653,401-141,682,221

IPCEF1

interaction protein for cytohesin exchange factors 1

26034

Q8WWN9

chr6: 154,154,496-154,356,792

GAB3

GRB2 associated binding protein 3

139716

Q8WWW8

chrX: 154,675,249-154,751,583

ARAP2

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

116984

Q8WZ64

chr4: 35,948,221-36,244,509

ELMO1

engulfment and cell motility 1

9844

Q92556

chr7: 36,854,361-37,449,249

ARHGEF2

Rho/Rac guanine nucleotide exchange factor 2

9181

Q92974

chr1: 155,946,851-156,007,070

DOCK10

dedicator of cytokinesis 10

55619

Q96BY6

chr2: 224,765,090-225,042,445

PLEKHB2

pleckstrin homology domain containing B2

55041

Q96CS7

chr2: 131,104,847-131,353,709

ARHGEF26

Rho guanine nucleotide exchange factor 26

26084

Q96DR7

chr3: 154,121,003-154,257,827

FGD4

FYVE, RhoGEF and PH domain containing 4

121512

Q96M96

chr12: 32,399,529-32,646,050

SPATA13

spermatogenesis associated 13

221178

Q96N96

chr13: 23,979,805-24,307,074

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

116985

Q96P48

chr11: 72,685,069-72,793,599

AGAP4

ArfGAP with GTPase domain, ankyrin repeat and PH domain 4

119016

Q96P64

chr10: 45,825,594-45,853,875

SYNGAP1

synaptic Ras GTPase activating protein 1

8831

Q96PV0

chr6: 33,419,661-33,457,541

OSBPL9

oxysterol binding protein like 9

114883

Q96SU4

chr1: 51,577,179-51,798,427

FAM129B

family with sequence similarity 129 member B

64855

Q96TA1

chr9: 127,505,339-127,578,989

DOK1

docking protein 1

1796

Q99704

chr2: 74,549,026-74,557,554

FERMT1

fermitin family member 1

55612

Q9BQL6

chr20: 6,074,845-6,123,544

OSBPL11

oxysterol binding protein like 11

114885

Q9BXB4

chr3: 125,528,858-125,595,090

OSBPL10

oxysterol binding protein like 10

114884

Q9BXB5

chr3: 31,657,890-32,077,580

OSBPL1A

oxysterol binding protein like 1A

114876

Q9BXW6

chr18: 24,162,044-24,397,880

OSBPL8

oxysterol binding protein like 8

114882

Q9BZF1

chr12: 76,351,797-76,559,809

OSBPL6

oxysterol binding protein like 6

114880

Q9BZF3

chr2: 178,194,481-178,402,891

PRKD2

protein kinase D2

25865

Q9BZL6

chr19: 46,674,275-46,717,127

SPTBN4

spectrin, beta, non-erythrocytic 4

57731

Q9H254

chr19: 40,466,241-40,576,464

TRIOBP

TRIO and F-actin binding protein

11078

Q9H2D6

chr22: 37,697,004-37,776,556

DEF6

DEF6, guanine nucleotide exchange factor

50619

Q9H4E7

chr6: 35,297,852-35,321,771

PLEKHA4

pleckstrin homology domain containing A4

57664

Q9H4M7

chr19: 48,837,097-48,868,632

PLEKHG2

pleckstrin homology and RhoGEF domain containing G2

64857

Q9H7P9

chr19: 39,412,585-39,428,415

PLEKHF2

pleckstrin homology and FYVE domain containing 2

79666

Q9H8W4

chr8: 95,133,804-95,156,684

PLEKHA5

pleckstrin homology domain containing A5

54477

Q9HAU0

chr12: 19,129,752-19,376,400

PLEKHA2

pleckstrin homology domain containing A2

59339

Q9HB19

chr8: 38,901,235-38,973,909

MYO10

myosin X

4651

Q9HD67

chr5: 16,661,914-16,936,276

ADAP2

ArfGAP with dual PH domains 2

55803

Q9NPF8

chr17: 30,906,344-30,959,322

ANLN

anillin actin binding protein

54443

Q9NQW6

chr7: 36,389,806-36,453,791

ARHGEF4

Rho guanine nucleotide exchange factor 4

50649

Q9NR80

chr2: 130,836,916-131,047,263

ARHGEF3

Rho guanine nucleotide exchange factor 3

50650

Q9NR81

chr3: 56,727,418-57,079,329

SH2B1

SH2B adaptor protein 1

25970

Q9NRF2

chr16: 28,846,600-28,874,212

PSD3

pleckstrin and Sec7 domain containing 3

23362

Q9NYI0

chr8: 18,527,301-19,084,730

PLEK2

pleckstrin 2

26499

Q9NYT0

chr14: 67,386,983-67,412,200

ITSN2

intersectin 2

50618

Q9NZM3

chr2: 24,202,864-24,360,714

DOK5

docking protein 5

55816

Q9P104

chr20: 54,475,597-54,651,171

ARHGAP23

Rho GTPase activating protein 23

57636

Q9P227

chr17: 38,419,280-38,512,392

ARHGAP20

Rho GTPase activating protein 20

57569

Q9P2F6

chr11: 110,577,042-110,713,189

PLEKHB1

pleckstrin homology domain containing B1

58473

Q9UF11

chr11: 73,646,178-73,662,819

VAV3

vav guanine nucleotide exchange factor 3

10451

Q9UKW4

chr1: 107,571,160-107,965,144

ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

50807

Q9ULH1

chr8: 130,052,104-130,443,660

PLEKHH1

pleckstrin homology, MyTH4 and FERM domain containing H1

57475

Q9ULM0

chr14: 67,533,301-67,589,612

ARHGAP26

Rho GTPase activating protein 26

23092

Q9UNA1

chr5: 142,770,384-143,229,011

AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

116987

Q9UPQ3

chr2: 235,494,089-236,131,800

PLCL2

phospholipase C like 2

23228

Q9UPR0

chr3: 16,802,651-17,090,594

TBC1D2B

TBC1 domain family member 2B

23102

Q9UPU7

chr15: 77,984,036-78,077,724

SH2B3

SH2B adaptor protein 3

10019

Q9UQQ2

chr12: 111,405,948-111,451,623

AKT3

v-akt murine thymoma viral oncogene homolog 3

10000

Q9Y243

chr1: 243,488,233-243,851,079

FARP1

FERM, ARH/RhoGEF and pleckstrin domain protein 1

10160

Q9Y4F1

chr13: 98,142,562-98,455,176

IRS2

insulin receptor substrate 2

8660

Q9Y4H2

chr13: 109,752,698-109,786,568

CDC42BPB

CDC42 binding protein kinase beta (DMPK-like)

9578

Q9Y5S2

chr14: 102,932,379-103,057,462